Unified synthesis of mono/bis-arylated phenols via RhIII-catalyzed dehydrogenative coupling.

Unified synthesis of mono/bis-arylated phenols via RhIII-catalyzed dehydrogenative coupling† †Electronic supplementary information (ESI) available: Experimental procedures and characterization data for all new compounds. CCDC 1047606, 1426755, 1438599 and 1442845. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6sc03169b Click here for additional data file. Click here for additional data file.

Efficient synthesis of anthranilic esters via Pd-catalyzed dehydrogenative/decarbonylative coupling of anilides and glyoxylates.

A novel way of synthesizing anthranilic esters was developed via Pd-catalyzed dehydrogenative/decarbonylative coupling between anilides and glyoxylates.

Iron-Catalyzed Oxidative C-H Functionalization of Internal Olefins for the Synthesis of Tetrasubstituted Furans.

Tetrasubstituted furans were efficiently synthesized from Fe(OAc)2-catalyzed C-H/C-H cross-dehydrogenative-coupling (CDC) reactions of activated carbonyl methylenes with S,S-functionalized internal olefins, that is, α-oxo ketene dithioacetals and analogues, under oxidative conditions. β-Ketoesters, 1,3-dicarbonyls, β-keto nitrile, and amide derivatives were used as the coupling partners. The re...

Directly fused highly substituted naphthalenes via Pd-catalyzed dehydrogenative annulation of N,N-dimethylaminomethyl ferrocene using a redox process with a substrate.

N,N-Dimethylaminomethyl ferrocenium could be generated in situ and served as a terminal oxidant for Pd-catalyzed directly dehydrogenative annulations of N,N-dimethylaminomethyl ferrocene and internal alkynes. This procedure utilized the redox activity of ferrocene and avoided adding an oxidant. A series of highly arylated naphthalenes functionalized by ferrocene were obtained in 53-81% yields.

Synthesis of benzimidazoles via iridium-catalyzed acceptorless dehydrogenative coupling.

Iridium-catalyzed acceptorless dehydrogenative coupling of tertiary amines and arylamines has been developed. A number of benzimidazoles were prepared in good yields. An iridium-mediated C-H activation mechanism is suggested. This finding represents a novel strategy for the synthesis of benzimidazoles.